منابع مشابه
MicroRNAs in age-related diseases
Aging is a complex process that is linked to an increased incidence of major diseases such as cardiovascular and neurodegenerative disease, but also cancer and immune disorders. MicroRNAs (miRNAs) are small non-coding RNAs, which post-transcriptionally control gene expression by inhibiting translation or inducing degradation of targeted mRNAs. MiRNAs target up to hundreds of mRNAs, thereby modu...
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the proportion of elderly in the general population is rising, resulting in greater numbers of drivers with neurodegenerative disorders such as alzheimer’s disease (ad) and parkinson’s disease (pd). alzheimer’s disease is a progressive neurodegenerative disorder typified by memory impairment with executive dysfunction, motor problems, and/or language difficulties. parkinson’s disease is a progr...
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The increase in the prevalence of obesity represents a worldwide phenomenon in all age groups and is pathologically and genetically correlated with several metabolic and cardiovascular diseases, representing the most frequent age-related diseases. Obesity superimposed on aging drastically increases chronic low-grade inflammation (inflammaging), which is an important link between obesity, insuli...
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The mitochondrial genome resides within mitochondria, the principal source of intracellular reactive oxygen species, and is thus exposed to far greater oxidative stress than nuclear DNA. The mitochondrial genome also demonstrates more intensive oxidative damage and a higher mutation rate than nuclear DNA. These facts are one reason for the age-related decline in the function of various tissues ...
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ژورنال
عنوان ژورنال: Geriatrics
سال: 2020
ISSN: 2308-3417
DOI: 10.3390/geriatrics5040080